My Diana 350Ms and P5have that off center breech also. And I've read about others wondering about what effect this has on their Diana models. Apparently, many models of Diana's line have that. As long as the pellet isn't getting clipped when you close the breech, or the seal leaking,I think you are ok. That was the consensus elsewhere where I was reading too. It was also mentioned that most folks couldn't understand how Diana screwed that one up...given their usual German qualty and engineering.
I've done a little deburring/crown on my Gamo shadow's transfer port, because it was chewing up the breech seal. I would also note that the chewed up breech seal had no negative effect on the velocity and was not leaking...this iscommonwith Shadow breech seals...but I saw a possible way to stop it, because I hate that. I took a drill bit that was very sharp and brand new and several sizes bigger than the port hole, and turned it by hand against the port, which shaved off a very small amount of metal, and left a rough crown behind. Then I took some valve grinding compound and put it on the port, ballistol for the polishing fluid, and used ahigh quality1/4"ball bearing to roll around on the port with my thumb, polishing the rough crown. After a few mintutes of me rolling the bearing around on the port, it was nice and polished. Then I completely washed everything to remove all traces of the grinding compound. No more chewed up seal.