Coyote's got some thick skull's and and that would be your best place for a shot placement with a magnum .22 or higher cal. airgun. As like most animal skull's there's a wide opening behind the eye and the bone thickness is thinner behind the eye and into the brain cavity. There are opening's for the eye socket muscle etc to run through and placeing a shot through here would shatter the inner shell behind the eye and enter the fusebox. The pellet selected would need to penatrate the eye, no problem then hit and shatter bone to enter the brain. The Predator has the ability to do this, I tested .22 cal's out on a cow skull with the Crosman TAC1.22 at 40yrd's. Five shot's into the side of the skull around the eye socket, all went through the inner skull plate and two exited out the other side. If attempted, make sure you got the time, shot placement and airgun to start and finish the job and most of all the ability. Not saying no one doesn't but watching a animal suffer will stick in one's mind for awhile. If you take a look at a past hunt by one of our great fellow Airgun hunter's (DAMAGE)in the Hunting Gate, he dropped a deer with a CFX.22. SHOT PLACEMENT! the creed of our hunter's here. Now I will be recieving what I like to call " THE MONSTER" !, she's tuned, mean and a workout just to cock but I think that together we will have the varment's running scared hehehe. I threw up a pic so that you got a idea of what's behind the mask, good luck and happy hunting. Ed