In general, I think, the higher the pellet velocity, the longer the distance to the target, and the lighter the pellet, the more difficult it is for me to hold tight groups. No mystery there. In my efforts to improve my accuracy, I think eliminating the variability of the weights of the individual pellets is a fairly easy thing to do, but I don't know how much absolute difference a quarter of a grain or so makes. Probably, it makes more difference with lighter (ie .177 vs. .20 or .22) pellets. And occasionally, I have run across an individual pellet that looks OK, but then found it's weight is way off -- certainly enough to theoretically cause the occasional flyer. I do know that when I shot weighed pellets, my velocities seem more consistent and I do know that if I am not grouping shots well, then I can now cross "variable pellet weights" off the list of potential causes.