Works the same as the smaller caliber version, but the larger bores do make better use of compressed gas (HPA/PCP/Co2)...just more pellet base area to push on. With springers, would want one of the bigger-beefier springers for .25 use. Just need to generate more volume of high pressure gas to get the .25 working well; the larger bore needs a larger volume of gas to maintain decent speeds.
If going .25, then a gun strong enough to shoot at lest the medium (24-25gr.) pellets, and the heavier weight Kodiaks (30.7gr.) would be even better. If just tossing 20-21gr. .25 pellets. may as well use a .22.
Have had an Exocet and a Stingray springer in .25 (both Wrbley products) and had no complaints. Big heavy pellets, lower speed, so trajectory was a bit loopy, but was certainly sadified with the performance on game (even at 40yards).
Currently have an HPA converted QB78 (converted to HPA and with a 23" LW .25 barrel) that is set to shoot Kodiaks to 685fps (about 32 foot pounds). Seldom have anything I really need to thump that hard, it certainly works on squirrels, but so does a .22 or .177. Once in a great while, have a garden raiding 'possum or racoon show up, which is where the .25 seems to do it's best work.