I have not owned other Gamos, but have shot a few and considered buying several...I still may. As you can see in my signature block I own a fair smattering of other springers, so I'm pretty familiar with the gammut.
The CFX, to me, is by far the best out of the box Gamo. Yes, it's a little twangy,ALL springers are, to one degree or another. Yes it has the Gamo trigger, not unshootable out of the box, and easily remedied with CDTs trigger. But, I think its combination of features and inherent accuracy are better than the break barrel Gamos, most other low to mid priced break barrels at that.
The CFX is the first, and so far, only underlever I have owned. I find the rotary breach block very easy to use and wouldn't see it as a problem for a left handed shooter. The comb on the monte carlo stock is ambidexterous, the same on both sides. You don't see that on most stocks. So, I think it would be one of the better choices for a lefty.
As far as I know, Pryamid is the only dealer offering the .22 CFX so far.
For the money, it is one of the best air rifles I have bought. This is why I would not hesitate to recommend it to anyone.